Optogenetic recruitment of hypothalamic corticotrophin-releasing-hormone (CRH) neurons reduces motivational drive

Abstract Impaired motivational drive is a key feature of depression. Chronic stress is a known antecedent to the development of depression in humans and depressive-like states in animals. Whilst there is a clear relationship between stress and motivational drive, the mechanisms underpinning this ass...

Full description

Bibliographic Details

Published in:	Translational Psychiatry
Main Authors:	Caitlin S. Mitchell, Erin J. Campbell, Simon D. Fisher, Laura M. Stanton, Nicholas J. Burton, Amy J. Pearl, Gavan P. McNally, Jaideep S. Bains, Tamás Füzesi, Brett A. Graham, Elizabeth E. Manning, Christopher V. Dayas
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-01-01
Online Access:	https://doi.org/10.1038/s41398-023-02710-0