Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-γ production via activating the JAK/STAT3 pathway during HIV infection

Abstract Background Natural killer (NK) cells play an important first-line role against tumour and viral infections and are regulated by inhibitory receptor expression. Among these inhibitory receptors, the expression, function, and mechanism of cluster of differentiation 47 (CD47) on NK cells durin...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Bin Lang, Meiting Wang, Zining Zhang, Yajing Fu, Xiaoxu Han, Qinghai Hu, Haibo Ding, Hong Shang, Yongjun Jiang
Format:	Article
Language:	English
Published:	BMC 2023-11-01
Subjects:	CD47 TSP1 IFN-γ NK cells JAK–STAT3 HIV infection
Online Access:	https://doi.org/10.1186/s12967-023-04667-6