Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts

Cancer-associated fibroblasts (CAFs) are non-cancerous cells found in solid tumors that remodel the tumor matrix and promote cancer invasion and angiogenesis. Here, we demonstrate that Cdc42EP3/BORG2 is required for the matrix remodeling, invasion, angiogenesis, and tumor-growth-promoting abilities...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Fernando Calvo, Romana Ranftl, Steven Hooper, Aaron J. Farrugia, Emad Moeendarbary, Andreas Bruckbauer, Facundo Batista, Guillaume Charras, Erik Sahai
Format:	Article
Language:	English
Published:	Elsevier 2015-12-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124715013832