DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition

Abstract Base excision repair, initiated by DNA glycosylases, preserves genomic integrity by removing damaged bases. DNA glycosylases Ogg1 and Mutyh were shown to alter the hippocampal transcriptome independently of DNA damage repair. However, the role of DNA glycosylases as transcriptional regulato...

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Bibliographic Details
Published in:Cellular and Molecular Life Sciences
Main Authors: Andreas Abentung, Teri Sakshaug, Rabina Dumaru, Nina-Beate Liabakk, Mingyi Yang, Junbai Wang, Magnar Bjørås, Katja Scheffler
Format: Article
Language:English
Published: Springer 2025-08-01
Subjects:
DNA glycosylase
PRC2
Epigenome
Transcription
Cognition
Online Access:https://doi.org/10.1007/s00018-025-05730-9

Internet

https://doi.org/10.1007/s00018-025-05730-9

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