The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis

Cytokinesis requires activation of the GTPase RhoA. ECT-2, the exchange factor responsible for RhoA activation, is regulated to ensure spatiotemporal control of contractile ring assembly. Centralspindlin, composed of the Rho family GTPase-activating protein (RhoGAP) MgcRacGAP/CYK-4 and the kinesin M...

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Bibliographic Details
Published in:eLife
Main Authors: Donglei Zhang, Michael Glotzer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Subjects:
cytokinesis
Rho GTPase
RhoGAP
RhoGEF
centralspindlin
Rac
Online Access:https://elifesciences.org/articles/08898

Internet

https://elifesciences.org/articles/08898

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