The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS

A method for the simultaneous quantification of urinary linoleic and arachidonic acid derived epoxides and diols, as well as the arachidonate omega hydroxylated product has been developed. The method employs negative mode electrospray ionization and HPLC with tandem mass spectroscopy for quantificat...

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Bibliographic Details

Published in:	Journal of Lipid Research
Main Authors:	John W. Newman, Takaho Watanabe, Bruce D. Hammock
Format:	Article
Language:	English
Published:	Elsevier 2002-09-01
Subjects:	epoxy fatty acids epoxyeicosatrienoic acid dihydroxyeicosatrienoic acid 20-hydroxyeicosatetraenoic acid leukotoxin soluble epoxide hydrolase
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520328212