Multiple-Molecule Drug Repositioning for Disrupting Progression of SARS-CoV-2 Infection by Utilizing the Systems Biology Method through Host-Pathogen-Interactive Time Profile Data and DNN-Based DTI Model with Drug Design Specifications

The coronavirus disease 2019 (COVID-19) pandemic has claimed many lives since it was first reported in late December 2019. However, there is still no drug proven to be effective against the virus. In this study, a candidate host–pathogen–interactive (HPI) genome-wide genetic and epigenetic network (...

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Bibliographic Details

Published in:	Stresses
Main Authors:	Cheng-Gang Wang, Bor-Sen Chen
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	SARS-CoV-2 COVID-19 systems biology reverse engineering principal network projection (PNP) drug–target interaction (DTI) model
Online Access:	https://www.mdpi.com/2673-7140/2/4/29