Clinical Relevance of Novel Polymorphisms in the Dihydropyrimidine Dehydrogenase (<i>DPYD</i>) Gene in Patients with Severe Fluoropyrimidine Toxicity: A Spanish Case-Control Study

Among cancer patients treated with fluoropyrimidines, 10–40% develop severe toxicity. Polymorphism of the dihydropyrimidine dehydrogenase (<i>DPYD</i>) gene may reduce DPD function, the main enzyme responsible for the metabolism of fluoropyrimidines. This leads to drug accumulation and t...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Paula Soria-Chacartegui, Gonzalo Villapalos-García, Luis A. López-Fernández, Marcos Navares-Gómez, Gina Mejía-Abril, Francisco Abad-Santos, Pablo Zubiaur
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	dihydropyrimidine dehydrogenase (<i>DPYD</i>) capecitabine 5-fluorouracil polymorphism pharmacogenetics
Online Access:	https://www.mdpi.com/1999-4923/13/12/2036