Challenges in HIV-1 Latent Reservoir and Target Cell Quantification in CAR-T Cell and Other Lentiviral Gene Modifying HIV Cure Strategies

Gene-modification therapies are at the forefront of HIV-1 cure strategies. Chimeric antigen receptor (CAR)-T cells pose a potential approach to target infected cells during antiretroviral therapy or following analytical treatment interruption (ATI). However, there are technical challenges in the qua...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Amanda M. Buck, Tyler-Marie Deveau, Timothy J. Henrich, Amelia N. Deitchman
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Subjects:	CAR-T cells HIV-1 cure HIV-1 envelope expression lentiviral vectors gene modification eradication
Online Access:	https://www.mdpi.com/1999-4915/15/5/1126