The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly pop...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Amanda McBride, Sarah Houtmann, Lindsay Wilde, Carlos Vigil, Christine M. Eischen, Margaret Kasner, Neil Palmisiano
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-03-01
Subjects:	BCL-2 venetoclax AML ALL MDS intrinsic apoptosis
Online Access:	https://www.frontiersin.org/article/10.3389/fonc.2019.00192/full