The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome

Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly pop...

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Bibliographic Details
Published in:Frontiers in Oncology
Main Authors: Amanda McBride, Sarah Houtmann, Lindsay Wilde, Carlos Vigil, Christine M. Eischen, Margaret Kasner, Neil Palmisiano
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Subjects:
BCL-2
venetoclax
AML
ALL
MDS
intrinsic apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00192/full
Description
Summary:Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.
ISSN:2234-943X

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