What Is the Best Predictor of Phenobarbital Pharmacokinetics to Use for Initial Dosing in Neonates?

Phenobarbital is a first-line treatment of various seizure types in newborns. Dosage individualization maximizing the proportion of patients with drug levels in therapeutic range or sufficient treatment response is still challenging. The aim of this review was to summarize the available evidence on...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Martin Šíma, Danica Michaličková, Ondřej Slanař
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Subjects:
Online Access:https://www.mdpi.com/1999-4923/13/3/301