Safe and potent anti‐CD19 CAR T‐cells with shRNA‐IL‐6 gene silencing element in patients with refractory or relapsed B‐cell acute lymphoblastic leukemia

Abstract Severe cytokine release syndrome (sCRS) and immune effector cell‐associated neurotoxicity syndrome (ICANS) have limited the widespread use of chimeric antigen receptor T (CAR T)‐cell therapy. We designed a novel anti‐CD19 CAR (ssCART‐19) with a small hairpin RNA (shRNA) element to silence t...

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Bibliographic Details

Published in:	HemaSphere
Main Authors:	Jin‐Feng Ma, Jia‐Wei Yan, Mei‐Jing Liu, Chun‐Long Yan, Xiao‐Wen Tang, Hui‐Ying Qiu, Miao Miao, Yue Han, Li‐Min Li, Li‐Qing Kang, Nan Xu, Zhou Yu, Jing‐Wen Tan, Hong‐Jia Zhu, Xu Jia, Zhi‐Zhi Zhang, Miao Wang, Hai‐Ping Dai, Lei Yu, Sheng‐Li Xue, De‐Pei Wu, Wen‐Jie Gong
Format:	Article
Language:	English
Published:	Wiley 2024-10-01
Online Access:	https://doi.org/10.1002/hem3.70007