The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse

The Thiamine Transporter 2 (THTR2) encoded by <i>SLC19A3</i> plays an ill-defined role in the maintenance of tissue thiamine, thiamine monophosphate, and thiamine diphosphate (TDP) levels. To evaluate the impact of THTR2 on tissue thiamine status and metabolism, we expressed the human &l...

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Bibliographic Details

Published in:	Metabolites
Main Authors:	Anita Wen, Ying Zhu, Sook Wah Yee, Brian I. Park, Kathleen M. Giacomini, Andrew S. Greenberg, John W. Newman
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Subjects:	thiamine thiamine transporter 2 THTR2 brain metabolism metabolomics
Online Access:	https://www.mdpi.com/2218-1989/13/8/885