Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study

Systemic sclerosis (SSc) is a rare multi-organ autoimmune disease characterized by progressive skin fibrosis. Inflammation, type 2 immunity, and fibrogenic processes are involved in disease development and may be affected by sphingolipids. However, details about early-stage pathophysiological mechan...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Katrin G. Schmidt, Martina Herrero San Juan, Sandra Trautmann, Lucija Berninger, Anja Schwiebs, Florian M. Ottenlinger, Dominique Thomas, Frank Zaucke, Josef M. Pfeilschifter, Heinfried H. Radeke
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-09-01
Subjects:	systemic sclerosis sphingosine-1-phosphate receptor 5 sphingolipid sphingosine-1-phosphate sphingolipids inflammation bleomycin
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01242/full