Brevilin A, a novel LRRC15 inhibitor, exerts potent anti-rheumatoid arthritis effects by inhibiting the LRRC15/STAT3 signaling pathway

Abstract Purpose Leucine-rich repeat-containing 15 (LRRC15) is a transmembrane protein that is highly expressed in the synovium of patients with rheumatoid arthritis (RA). Brevilin A (BrA), an active compound isolated from Centipeda minima, exerts potent anti-inflammatory effects. However, the anti-...

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Bibliographic Details

Published in:	Arthritis Research & Therapy
Main Authors:	Zhiping Qiao, Qiqi Meng, Bixia Xiao, Yulei Long, Qi Liang, Tao Su
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Subjects:	Rheumatoid arthritis Brevilin A Rheumatoid arthritis-fibroblast-like synoviocyte LRRC15 STAT3
Online Access:	https://doi.org/10.1186/s13075-025-03629-1