CaClust: linking genotype to transcriptional heterogeneity of follicular lymphoma using BCR and exomic variants

Abstract Tumours exhibit high genotypic and transcriptional heterogeneity. Both affect cancer progression and treatment, but have been predominantly studied separately in follicular lymphoma. To comprehensively investigate the evolution and genotype-to-phenotype maps in follicular lymphoma, we intro...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Kazimierz Oksza-Orzechowski, Edwin Quinten, Shadi Shafighi, Szymon M. Kiełbasa, Hugo W. van Kessel, Ruben A. L. de Groen, Joost S. P. Vermaat, Julieta H. Sepúlveda Yáñez, Marcelo A. Navarrete, Hendrik Veelken, Cornelis A. M. van Bergen, Ewa Szczurek
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Subjects:	Cancer genetics Tumour heterogeneity Statistical methods Follicular lymphoma
Online Access:	https://doi.org/10.1186/s13059-024-03417-1