Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys

BackgroundHypoxia contributes to a cascade of inflammatory response mechanisms in kidneys that result in the development of renal interstitial fibrosis and subsequent chronic renal failure. Nonetheless, the kidney possesses a self-protection mechanism under a certain degree of hypoxia and this mecha...

Full description

Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Yaya Xu, Xiangmei Kong, Jiru Li, Tiantian Cui, Yifan Wei, Jiayue Xu, Yueniu Zhu, Xiaodong Zhu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Subjects:	kidney injury VEGF HIF-1 chronic hypoxia vascularization
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2021.690496/full