Factors Influencing the Prevalence of Resistance-Associated Substitutions in NS5A Protein in Treatment-Naive Patients with Chronic Hepatitis C

Direct-acting antivirals (DAAs) revolutionized treatment of hepatitis C virus (HCV) infection. Resistance-associated substitutions (RASs) present at the baseline impair response to DAA due to rapid selection of resistant HCV strains. NS5A is indispensable target of the current DAA treatment regimens...

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发表在:	Biomedicines
Main Authors:	Karen K. Kyuregyan, Vera S. Kichatova, Anastasiya A. Karlsen, Olga V. Isaeva, Sergei A. Solonin, Stefan Petkov, Morten Nielsen, Maria G. Isaguliants, Mikhail I. Mikhailov
格式:	文件
语言:	英语
出版:	MDPI AG 2020-04-01
主题:	hepatitis C virus (HCV) NS5A resistance-associated substitutions direct-acting antivirals amino acid covariance immune escape
在线阅读:	https://www.mdpi.com/2227-9059/8/4/80