Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness

Breast cancer stem cells (BCSCs) are intrinsically chemoresistant and capable of self-renewal. Following chemotherapy, patients can develop minimal residual disease due to BCSCs which can repopulate into a relapsed tumor. Therefore, it is imperative to co-target BCSCs along with the bulk tumor cells...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Sangita Sridharan, Megan Robeson, Diwakar Bastihalli-Tukaramrao, Cory M. Howard, Boopathi Subramaniyan, Augustus M. C. Tilley, Amit K. Tiwari, Dayanidhi Raman
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-12-01
Subjects:	breast cancer stemness eIF4A Rocaglamide A chemoresistance actionable targets cell death
Online Access:	https://www.frontiersin.org/article/10.3389/fonc.2019.01311/full