Tuft cells trigger neurogenic inflammation in the urethra

Summary: Cholinergic urethral tuft cells (UTCs) are regarded as sentinels of microbial products in the urogenital tract, initiating reflex micturition as a protective mechanism. We here hypothesize that acetylcholine released by stimulated UTC leads to neurogenic inflammation by triggering neuropept...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Patricia Schmidt, Uwe Pfeil, Mahmoud Lafee, Swantje Petersen, Alexander Perniss, Maryam Keshavarz, Debajyoti Das, Amanda Wyatt, Ulrich Boehm, Burkhard Schütz, Wolfgang Kummer, Klaus Deckmann
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	CP: Neuroscience CP: Immunology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124725011416