Design and Synthesis of D₃R Bitopic Ligands with Flexible Secondary Binding Fragments: Radioligand Binding and Computational Chemistry Studies

A series of bitopic ligands based on Fallypride with a flexible secondary binding fragment (SBF) were prepared with the goal of preparing a D₃R-selective compound. The effect of the flexible linker (<b>(<i>R</i></b>,<b><i>S</i>)<i&g...

Full description

Bibliographic Details

Published in:	Molecules
Main Authors:	Gui-Long Tian, Chia-Ju Hsieh, Michelle Taylor, Ji Youn Lee, Robert R. Luedtke, Robert H. Mach
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Subjects:	dopamine 2 receptor dopamine 3 receptor flexible linker bitopic ligands molecular dynamic simulation
Online Access:	https://www.mdpi.com/1420-3049/29/1/123