Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways

Hyperuricemia is a key risk factor for chronic kidney disease (CKD), yet effective treatments remain limited. This study demonstrates that quercetin exerts potent renoprotective effects in hyperuricemia-induced CKD through multifaceted mechanisms. In rats with hyperuricemia induced by adenine (0.1 g...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Huan Liu, Qi Yang, Shuiying Wang, Tingting Wang, Lihua Pan, Xue Wang, Yangfeng Chi, Zhouhui Jin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	quercetin hyperuricemia kidney injury inflammation fibrosis oxidative stress
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1660599/full