IgA and IgG1 Specific to Vi Polysaccharide of Salmonella Typhi Correlate With Protection Status in a Typhoid Fever Controlled Human Infection Model

Vaccination against Salmonella Typhi using the Vi capsular polysaccharide, a T-cell independent antigen, can protect from the development of typhoid fever. This implies that antibodies to Vi alone can protect in the absence of a T cell-mediated immune response; however, protective Vi antibodies have...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Lindsay C. Dahora, Celina Jin, Rachel L. Spreng, Frederick Feely, Ryan Mathura, Kelly E. Seaton, Lu Zhang, Jennifer Hill, Elizabeth Jones, S. Munir Alam, S. Moses Dennison, Andrew J. Pollard, Georgia D. Tomaras
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-11-01
Subjects:	typhoid fever Salmonella Typhi (S. Typhi) Vi polysaccharide correlates of protection (CoP) humoral immunity vaccination
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02582/full