Apoptotic vesicles are required to repair DNA damage and suppress premature cellular senescence

Abstract It is well known that DNA damage can cause apoptosis. However, whether apoptosis and its metabolites contribute to DNA repair is largely unknown. In this study, we found that apoptosis‐deficient Fasmut and Bim−/− mice show significantly elevated DNA damage and premature cellular senescence,...

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Bibliographic Details

Published in:	Journal of Extracellular Vesicles
Main Authors:	Zhiqing Huang, Yuzhi Zhuang, Wenwen Li, Mingchen Ma, Fangcao Lei, Yan Qu, Jiaqi Li, Huigen Luo, Changzheng Li, Lu Lu, Lan Ma, Xiao Zhang, Xiaoxing Kou, Linjia Jiang, Xueli Mao, Songtao Shi
Format:	Article
Language:	English
Published:	Wiley 2024-04-01
Subjects:	apoptosis apoptotic vesicles DNA damage repair DDR‐apoV complexes embryonic stem cells mesenchymal stromal cells
Online Access:	https://doi.org/10.1002/jev2.12428