A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

Triple negative breast cancers (TNBC) remain a major medical challenge due to poor prognosis and limited treatment options. Mesothelin is a glycosyl-phosphatidyl inositol-linked membrane protein with restricted normal expression and high level expression in a large proportion of TNBC, thus qualifyin...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Joanie Del Bano, Rémy Florès-Florès, Emmanuelle Josselin, Armelle Goubard, Laetitia Ganier, Rémy Castellano, Patrick Chames, Daniel Baty, Brigitte Kerfelec
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-07-01
Subjects:	bispecific antibody (bsAb) natural killer cells immunotherapy triple negative breast cancer (TNBC) mesothelin (MSLN) multicellular tumor spheroid model (MCTS)
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01593/full