Roles of neuropathology-associated reactive astrocytes: a systematic review

Abstract In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or neuroinflammatory reactive astrocytes. In contrast to typical astrocytes, which promote neuronal survival...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Jill M. Lawrence, Kayla Schardien, Brian Wigdahl, Michael R. Nonnemacher
Format:	Article
Language:	English
Published:	BMC 2023-03-01
Subjects:	Neurotoxic reactive astrocytes Activated astrocytes A1 astrocytes Neuroinflammation Neurodegeneration
Online Access:	https://doi.org/10.1186/s40478-023-01526-9