PRMT5-mediated FUBP1 methylation accelerates prostate cancer progression

Strategies beyond hormone-related therapy need to be developed to improve prostate cancer mortality. Here, we show that FUBP1 and its methylation were essential for prostate cancer progression, and a competitive peptide interfering with FUBP1 methylation suppressed the development of prostate cancer...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Weiwei Yan, Xun Liu, Xuefeng Qiu, Xuebin Zhang, Jiahui Chen, Kai Xiao, Ping Wu, Chao Peng, Xiaolin Hu, Zengming Wang, Jun Qin, Liming Sun, Luonan Chen, Denglong Wu, Shengsong Huang, Lichen Yin, Zhenfei Li
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2024-09-01
Subjects:	Oncology Therapeutics
Online Access:	https://doi.org/10.1172/JCI175023