High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer

DNA mismatch repair (MMR)-deficient cancers accumulate high numbers of coding microsatellite mutations, which lead to the generation of highly immunogenic frameshift peptide (FSP) neoantigens. MMR-deficient cells can grow out to clinically manifest cancers either if they evade immune cell attack or...

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Bibliographic Details

Published in:	OncoImmunology
Main Authors:	Jonas Janikovits, Meike Müller, Julia Krzykalla, Sandrina Körner, Fabian Echterdiek, Bernd Lahrmann, Niels Grabe, Martin Schneider, Axel Benner, Magnus von Knebel Doeberitz, Matthias Kloor
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-02-01
Subjects:	beta2-microglobulin colorectal cancer immune checkpoints immunoediting microsatellite instability pdcd1 (pd-1) tumor-infiltrating lymphocytes mismatch repair deficiency
Online Access:	http://dx.doi.org/10.1080/2162402X.2017.1390640