Along the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evolution from Fish to Mammals

A phenomenon already discovered more than 25 years ago is the possibility of naïve helper T cells to polarize into TH1 or TH2 populations. In a simplified model, these polarizations occur at opposite ends of an “immune 1-2 axis” (i1-i2 axis) of possible conditions. Additional polarizations of helper...

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Bibliographic Details

Published in:	Biology
Main Authors:	Takuya Yamaguchi, Fumio Takizawa, Uwe Fischer, Johannes M. Dijkstra
Format:	Article
Language:	English
Published:	MDPI AG 2015-11-01
Subjects:	immunology evolution fish TH1 TH17 Treg TH2 i1-i2 axis cytokines IL-5
Online Access:	http://www.mdpi.com/2079-7737/4/4/814