Characterization of the Binding and Inhibition Mechanisms of a Novel Neutralizing Monoclonal Antibody Targeting the Stem Helix Region in the S2 Subunit of the Spike Protein of SARS-CoV-2

Background/Objectives: For viral entry into host cells, the spike (S) protein of coronavirus (CoV) uses its S1 domain to bind to the host receptor and S2 domain to mediate the fusion between virion and cellular membranes. The S1 domain acquired multiple mutations as the severe acute respiratory synd...

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Bibliographic Details

Published in:	Vaccines
Main Authors:	Selene Si Ern Tan, Ee Hong Tam, Kah Man Lai, Yanjun Wu, Tianshu Xiao, Yee-Joo Tan
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Subjects:	SARS-CoV-2 spike protein monoclonal antibodies
Online Access:	https://www.mdpi.com/2076-393X/13/7/688