Chemokine receptor CXCR4 activates the RhoA/ROCK2 pathway in spinal neurons that induces bone cancer pain

Background Chemokine receptor CXCR4 has been found to be associated with spinal neuron and glial cell activation during bone cancer pain. However, the underlying mechanism remains unknown. Furthermore, the RhoA/ROCK2 pathway serves as a downstream pathway activated by CXCR4 during bone cancer pain....

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Bibliographic Details

Published in:	Molecular Pain
Main Authors:	Heng Xu, Chong Peng, Xue-Tai Chen, Ying-Ying Yao, Li-Ping Chen, Qin Yin, Wen Shen
Format:	Article
Language:	English
Published:	SAGE Publishing 2020-04-01
Online Access:	https://doi.org/10.1177/1744806920919568