Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum

Plasmodium falciparum is the deadliest causative agent of human malaria. This parasite has historically developed resistance to most drugs, including the current frontline treatments, so new therapeutic targets are needed. Our previous work on guanine quadruplexes (G4s) in the parasite's DNA an...

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Bibliographic Details

Published in:	International Journal for Parasitology: Drugs and Drug Resistance
Main Authors:	Holly M. Craven, Guilherme Nettesheim, Pietro Cicuta, Andrew M. Blagborough, Catherine J. Merrick
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	Malaria Plasmodium G-quadruplex quarfloxin CX-5461 repositioning
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211320723000404