Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning

Cancer stem cells (CSCs) undergo epithelial-mesenchymal transition (EMT) to drive metastatic dissemination in experimental cancer models. However, tumour cells undergoing EMT have not been observed disseminating into the tissue surrounding human tumour specimens, leaving the relevance to human cance...

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Bibliographic Details
Published in:eLife
Main Authors: Gehad Youssef, Luke Gammon, Leah Ambler, Sophia Lunetto, Alice Scemama, Hannah Cottom, Kim Piper, Ian C Mackenzie, Michael P Philpott, Adrian Biddle
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-11-01
Subjects:
cancer stem cell
oral cancer
metastasis
machine learning
multiplexed imaging
prognosis
Online Access:https://elifesciences.org/articles/90298

Internet

https://elifesciences.org/articles/90298

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