A type-specific B-cell epitope at the apex of outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

ABSTRACT Broadly protective immunity to the Lyme disease spirochete, Borreliella burgdorferi, is constrained by antibodies against type-specific epitopes on outer surface protein C (OspC), a homodimeric helix-rich lipoprotein essential for early stages of spirochete dissemination in vertebrate hosts...

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Bibliographic Details
Published in:Microbiology Spectrum
Main Authors: David J. Vance, Grace Freeman-Gallant, Kathleen McCarthy, Carol Lyn Piazza, Yang Chen, Clint Vorauer, Beatrice Muriuki, Michael J. Rudolph, Lisa Cavacini, Miklos Guttman, Nicholas J. Mantis
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Subjects:
vaccine
antibody
epitope
neutralizing
human
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02883-24

Internet

https://journals.asm.org/doi/10.1128/spectrum.02883-24

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