Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity

The comprehensive assessment of long-term effects of reducing intake of energy (CALERIE-II; NCT00427193) clinical trial established that caloric restriction (CR) in humans lowers inflammation. The identity and mechanism of endogenous CR-mimetics that can be deployed to control obesity-associated inf...

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Bibliographic Details

Published in:	The Journal of Clinical Investigation
Main Authors:	Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, Aileen H. Lee, Sonia Caprio, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Maxim N. Artyomov, Yun-Hee Youm, Vishwa Deep Dixit
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2023-10-01
Subjects:	Inflammation Metabolism
Online Access:	https://doi.org/10.1172/JCI169173