The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

Summary: Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. Adhesion G protein-coupled receptors (aGPCRs) have attracted interest for their potential as treatment targets. Here, we show that CD97 (ADGRE5) is the most promising aGPCR target in GBM, by virtue of its de novo...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Niklas Ravn-Boess, Nainita Roy, Takamitsu Hattori, Devin Bready, Hayley Donaldson, Christopher Lawson, Cathryn Lapierre, Aryeh Korman, Tori Rodrick, Enze Liu, Joshua D. Frenster, Gabriele Stephan, Jordan Wilcox, Alexis D. Corrado, Julia Cai, Rebecca Ronnen, Shuai Wang, Sara Haddock, Jonathan Sabio Ortiz, Orin Mishkit, Alireza Khodadadi-Jamayran, Aris Tsirigos, David Fenyö, David Zagzag, Julia Drube, Carsten Hoffmann, Fabiana Perna, Drew R. Jones, Richard Possemato, Akiko Koide, Shohei Koide, Christopher Y. Park, Dimitris G. Placantonakis
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	CP: Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723013864