DiNeR: a Differential graphical model for analysis of co-regulation Network Rewiring

Abstract Background During transcription, numerous transcription factors (TFs) bind to targets in a highly coordinated manner to control the gene expression. Alterations in groups of TF-binding profiles (i.e. “co-binding changes”) can affect the co-regulating associations between TFs (i.e. “rewiring...

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Bibliographic Details

Published in:	BMC Bioinformatics
Main Authors:	Jing Zhang, Jason Liu, Donghoon Lee, Shaoke Lou, Zhanlin Chen, Gamze Gürsoy, Mark Gerstein
Format:	Article
Language:	English
Published:	BMC 2020-07-01
Subjects:	Transcription factor co-regulation network ENCODE TF dysregulation Network changes
Online Access:	http://link.springer.com/article/10.1186/s12859-020-03605-3