Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions

Leptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance. This review synthesizes animal and clinical evidence on leptin’s role in obesity, focusing...

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Bibliographic Details
Published in:Endocrine Connections
Main Authors: Wenjing Hu, Huijuan Zhu, Fengying Gong
Format: Article
Language:English
Published: Bioscientifica 2025-09-01
Subjects:
Online Access:https://ec.bioscientifica.com/view/journals/ec/14/9/EC-25-0521.xml