A parameterized two-domain thermodynamic model explains diverse mutational effects on protein allostery

New experimental findings continue to challenge our understanding of protein allostery. Recent deep mutational scanning study showed that allosteric hotspots in the tetracycline repressor (TetR) and its homologous transcriptional factors are broadly distributed rather than spanning well-defined stru...

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Bibliographic Details

Published in:	eLife
Main Authors:	Zhuang Liu, Thomas G Gillis, Srivatsan Raman, Qiang Cui
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-06-01
Subjects:	allostery thermodynamic model allosteric hotspots Bayesian inference epistasis
Online Access:	https://elifesciences.org/articles/92262