Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects

Abstract Periodontitis is a critical risk factor for the occurrence and development of diabetes. Porphyromonas gingivalis may participate in insulin resistance (IR) caused by periodontal inflammation, but the functional role and specific mechanisms of P. gingivalis in IR remain unclear. In the prese...

Full description

Bibliographic Details

Published in:	International Journal of Oral Science
Main Authors:	Fen Liu, Bofeng Zhu, Ying An, Zhifei Zhou, Peiying Xiong, Xuan Li, Yang Mi, Tongqiang He, Faming Chen, Buling Wu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-08-01
Online Access:	https://doi.org/10.1038/s41368-024-00313-z