Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

Summary: Apolipoprotein E (apoE) plays a crucial role in the pathogenesis of Alzheimer’s disease (AD). Microglia exhibit a substantial upregulation of apoE in AD-associated circumstances, despite astrocytes being the primary source of apoE expression and secretion in the brain. Although the role of...

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Bibliographic Details

Published in:	iScience
Main Authors:	Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-fen Chen, Lige Leng, Yun-wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi Xu
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Biological sciences Cellular neuroscience Neuroscience Transcriptomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224012318