Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs)

Background/Aims: Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into several lineages including bone. Successful bone formation requires osteogenesis and angiogenesis coupling of MSCs. Here, we investigate if simultaneous activation of BMP9 and Notch signaling yield...

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Bibliographic Details

Published in:	Cellular Physiology and Biochemistry
Main Authors:	Junyi Liao, Qiang Wei, Yulong Zou, Jiaming Fan, Dongzhe Song, Jing Cui, Wenwen Zhang, Yunxiao Zhu, Chao Ma, Xue Hu, Xiangyang Qu, Liqun Chen, Xinyi Yu, Zhicai Zhang, Claire Wang, Chen Zhao, Zongyue Zeng, Ruyi Zhang, Shujuan Yan, Tingting Wu, Xingye Wu, Yi Shu, Jiayan Lei, Yasha Li, Hue H. Luu, Michael J. Lee, Russell R. Reid, Guillermo A. Ameer, Jennifer Moriatis Wolf, Tong-Chuan He, Wei Huang
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2017-04-01
Subjects:	BMP9 signaling Notch signaling Osteogenesis-angiogenesis coupling Mesenchymal stem cells Bone repair Regenerative medicine
Online Access:	http://www.karger.com/Article/FullText/471945