Magnesium ions facilitate osteogenic differentiation and intervertebral fusion via m6A methylation of RhoA mRNA

Background: Magnesium-based implants facilitate bone regeneration via degradation. However, the epigenetic mechanisms, particularly N6-methyladenosine (m6A) modification regulated by Mg2+, remain incompletely understood. This study investigated the role of Mg2+ in osteogenic differentiation through...

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Bibliographic Details

Published in:	Journal of Orthopaedic Translation
Main Authors:	Haocheng Xu, Linli Li, Fan Zhang, Minghao Shao, Chenyan Li, Yitong Xue, Dachuan Li, Zhidi Lin, Zhaoyang Gong, Jiongdong Wu, Zhiwen Luo, Zhicai Shi, Xinlei Xia, Hongli Wang, Xiaosheng Ma, Jianyuan Jiang, Xiaochuan Gu, Yang Liu, Xiao Lu, Feizhou Lyu
Format:	Article
Language:	English
Published:	Elsevier 2026-03-01
Subjects:	Intervertebral fusion Magnesium ions METTL3 m6A modification Osteogenic differentiation RhoA/ROCK pathway
Online Access:	http://www.sciencedirect.com/science/article/pii/S2214031X26000112