The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir.

Lenacapavir (LEN) is a highly potent, long-acting antiretroviral medication for treating people infected with muti-drug-resistant HIV-1 phenotypes. The inhibitor targets multifaceted functions of the viral capsid protein (CA) during HIV-1 replication. Previous studies have mainly focused on elucidat...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Szu-Wei Huang, Lorenzo Briganti, Arun S Annamalai, Juliet Greenwood, Nikoloz Shkriabai, Reed Haney, Michael L Armstrong, Michael F Wempe, Satya Prakash Singh, Ashwanth C Francis, Alan N Engelman, Mamuka Kvaratskhelia
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-01-01
Online Access:	https://doi.org/10.1371/journal.ppat.1012862