The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. T cells must substantially increase nutrient uptake to mount a proper immune response and failure to obtain sufficient nutrients or...

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Bibliographic Details

Published in:	eLife
Main Authors:	Aaron R Lim, W Kimryn Rathmell, Jeffrey C Rathmell
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-05-01
Subjects:	immunometabolism tumor microenvironment tumor-infiltrating lymphocytes t cells immunotherapy cancer
Online Access:	https://elifesciences.org/articles/55185