An optimized temporally controlled Gal4 system in Drosophila reveals degeneration caused by adult-onset neuronal Vps13D knockdown

Mutations in the human gene VPS13D cause the adult-onset neurodegenerative disease ataxia. Our previous work showed that disruptions in the Vps13D gene in Drosophila neurons causes mitochondrial defects. However, developmental lethality caused by Vps13D loss limited our understanding of the long-ter...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Emily Rozich, Lynsey K. Randolph, Ryan Insolera
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	VPS13D-related disorders mitophagy ataxia neurodegenerative disease VPS13D mitochondria
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1204068/full