Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation
Freeze-thaw cycles impact the amount of aggregation observed in antibodies and Fc-fusion proteins. Various formulation strategies are used to mitigate the amount of aggregation that occurs upon putting a protein solution through a freeze-thaw cycle. Additionally, low pH solutions cause native antibo...
| Published in: | Journal of Pharmaceutical Analysis |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-10-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177917301120 |