P2X7 Receptor Modulation of the Gut Microbiota and the Inflammasome Determines the Severity of <i>Toxoplasma gondii</i>-Induced Ileitis

In mice, oral <i>Toxoplasma gondii</i> infection induces severe ileitis. The aim of the present study was to investigate the impact of the P2X7 receptor (P2X7) on the inflammatory response to <i>T. gondii</i>-induced ileitis. Cysts of the ME49 strain of <i>T. gondii<...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Aline Cristina Abreu Moreira-Souza, Hayandra Ferreira Nanini, Thuany Prado Rangel, Sthefani Rodrigues Batista da Silva, Beatriz Pêgo Damasceno, Beatriz Elias Ribeiro, Cynthia M. Cascabulho, Fabiano Thompson, Camille Leal, Patrícia Teixeira Santana, Siane Lopes Bittencourt Rosas, Kívia Queiroz de Andrade, Claudia L. Martins Silva, Rossiane Claudia Vommaro, Heitor Siffert Pereira de Souza, Robson Coutinho-Silva
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Subjects:	gut microbiota inflammasome purinergic signaling P2X7 receptor <i>Toxoplasma gondii</i> ileitis
Online Access:	https://www.mdpi.com/2227-9059/11/2/555