Inhibition of CXXC5 function rescues Alzheimer’s disease phenotypes by restoring Wnt/β-catenin signaling pathway

Alzheimer’s disease (AD) is the most prevalent type of dementia and is characterized by cognitive deficits and accumulation of pathological plaques. Owing to the complexity of AD development, paradigms for AD research and drug discovery have shifted to target factors that mediate multiple pathogenes...

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Bibliographic Details

Published in:	Pharmacological Research
Main Authors:	Minguen Yoon, Heejene Kim, Heewon Shin, HeeYang Lee, Min-Jeong Kang, Sung-Hye Park, Gyoonhee Han, YoungSoo Kim, Kang-Yell Choi
Format:	Article
Language:	English
Published:	Elsevier 2023-08-01
Subjects:	Alzheimer’s disease 5xFAD Wnt/β-catenin signaling pathway CXXC5 Cxxc5-/-/5xFAD mice CXXC5-Dvl protein-protein interaction
Online Access:	http://www.sciencedirect.com/science/article/pii/S1043661823001925